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M94A2943.TXT
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1994-10-25
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Document 2943
DOCN M94A2943
TI Combined p24 antigen and anti-p66 as markers of AIDS-free time.
DT 9412
AU Henrard D; Meiszberg T; Wiesner D; Goedert J; Abbott Labs, Abbott Park,
IL.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):19 (abstract no. 050B). Unique
Identifier : AIDSLINE ICA10/94369632
AB OBJECTIVE: Assess levels of specific HIV-1 antibodies as early predictor
of AIDS-free time, especially in p24-antigen (Ag) negative subjects.
METHODS: Two to ten (mean 5.5) annual samples from 30 homosexual men
with documented seroconversion dates were studied. Seven men developed
AIDS in 3 years (group I), 11 developed AIDS in 4-6 years (group II) and
13 did not develop AIDS in 7 years (group III). HIV-1 p24-Ag was
detected by a monoclonal EIA; levels of antibody to gp120, gp41, p66,
p31, p24 and p17 were measured by dot-blot EIA. RESULTS: Within 2 years
of seroconversion, p24 antigen was detected in 7/7 men in group I, 5/11
men in group II and 3/13 in group III. Anti-p66 levels were stable or
increasing in 11 (84%) of 13 group III men vs 4 (36%) of 11 group II
men. Among p24-Ag negative men, those with stable or increasing levels
of anti-p66 were 18 times more likely to be in group III than in group
II. Other antibodies did not as clearly discriminate groups II and III
in p24-Ag negative men. CONCLUSION: For individuals who remain negative
for p24-Ag during the early years of infection, decreasing anti-p66 may
indicate a higher risk of AIDS progression within 4-6 years.
DE Biological Markers Human HIV Antibodies/*ISOLATION & PURIF HIV Core
Protein p24/*IMMUNOLOGY HIV Envelope Protein gp120/IMMUNOLOGY HIV
Seropositivity/*IMMUNOLOGY Immunoenzyme Techniques Male MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).